秦波-化学理论与机制重庆市重点实验室主页

秦波博士副教授（博导）

专业有机化学超分子化学

简历

1998-2002 四川大学化学专业学习，获理学学士学位;

2002-2007 四川大学有机化学专业学习，获理学博士学位，导师：冯小明院士;

2007-2010 新加坡国立大学化学系做博士后研究，合作导师Prof. Zeng Huaqiang;

2010-2011 新加坡南洋理工大学新加坡膜技术研究中心做博士后研究，合作导师：Prof. Wang Rong和Prof.Zeng Huaqiang;

2013-2014 美国莱斯大学（BioScience Research Collaborative）做博士后研究，合作导师：Prof. K.C. Nicolaou;

2011-2013 重庆大学化学化工学院讲师;

2013- 重庆大学化学化工学院副教授、博士生导师

联系方式

邮箱：qinbo@cqu.edu.cn，电话：15086803067，办公室：LC713

研究方向和项目

研究方向

研究主要从事超分子化学、多肽合成、不对称合成等领域的科研工作。现已发表SCI收录论文30余篇，在国际重要刊物如：J.Am.Chem.Soc.; Chem. Commun.; Org. Lett.; Chem.-Eur. J.; J.Org. Chem.等发表的论文。获得国家教育部2010年自然科学一等奖。承担国家自然科学基金2项。

1. 功能性有机分子材料的设计，合成和应用;

2. 不对称合成方法学，新合成方法与手段，涉及手性医药、农药和具有生理活性化合物的合成研究。

研究项目：

1. 军委科技委创新项目（课题负责人，2017-2018）；

2. 重庆市人工智能科技创新重大主体专项，重点研发项目（主研，2018.1-2019.12）；

3. 国家自然科学基金(21272293, 课题负责人，2013-2016): 金属离子识别的荧光传感器可控制备与应用研究；

4. 重庆大学人才引进项目(课题负责人，2012-2015) ；

5. 国家自然科学基金项目（20702033,课题负责人，2008-2010)：新型双中心催化剂催化酮的不对称Henry 反应研究；

6. 国家自然科学基金项目（20602025,主研，2007-2009）：手性有机酸盐催化酮的不对称腈化反应研究，

代表性论文、专著和专利

论文

34. Wu, Q .; Tu, F.; Long, L.; Qin, B.*, Self-Assembly of Intramolecularly Hydrogen-Bonded Amphiphilic Diboronic Acid for Saccharide Recognition Org. Biomol. Chem.，2018，submitted.

33. Nicolaou, K. C.*; Cai, Q.; Sun, H. B.; Qin, B.; Zhu, S. G., Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7"-epi-C and Full Structural Assignment of Trioxacarcin C. J. Am. Chem. Soc.2016, 138 (9), 3118-3124.

32. Nicolaou, K. C.*; Cai, Q.; Qin, B.; Petersen, M. T.; Mikkelsen, R. J. T.; Heretsch, P., Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Edit.2015, 54 (10), 3074-3078.

31. Fu, H. L.; Chang, H.; Shen, J.; Yu, L.; Qin, B.; Zhang, K.; Zeng, H. Q., An unusual macrocyclization reagent for highly selective one-pot synthesis of strained macrocyclic aromatic hexamers. Chem. Commun. 2014, 50 (27), 3582-3584.

30. Sun, C.; Ren, C. L.; Wei, Y. C.; Qin, B.; Zeng, H. Q., Patterned recognition of amines and ammonium ions by a stimuli-responsive foldamer-based hexameric oligophenol host. Chem. Commun.2013, 49 (46), 5307-5309.

29. Liu, Y.; Qin, B.; Zeng, H. Q., POCl3-mediated H-bonding-directed one-pot synthesis of macrocyclic pentamers, strained hexamers and highly strained heptamers. Sci. China Chem.2012, 55 (1), 55-63.

28. Du, Z. Y.; Qin, B.; Sun, C.; Liu, Y.; Zheng, X.; Zhang, K.; Conney, A. H.; Zeng, H. Q., Folding-promoted TBAX-mediated selective demethylation of methoxybenzene-based macrocyclic aromatic pentamers.Org. Biomol. Chem. 2012, 10 (21), 4164-4171.

27. Ren, C. L.; Zhou, F.; Qin, B.; Ye, R. J.; Shen, S.; Su, H. B.; Zeng, H. Q., Crystallographic Realization of the Mathematically Predicted Densest All-Pentagon Packing Lattice by C-5-Symmetric "Sticky" Fluoropentamers. Angew. Chem. In.t Edit 2011, 50 (45), 10612-10615.

26. Qin, B.; Sun, C.; Liu, Y.; Shen, J.; Ye, R. J.; Zhu, J.; Duan, X. F.; Zeng, H. Q., One-Pot Synthesis of Hybrid Macrocyclic Pentamers with Variable Functionalizations around the Periphery. Org. Lett. 2011, 13 (9), 2270-2273.

25. Qin, B.; Shen, S.; Sun, C.; Du, Z. Y.; Zhang, K.; Zeng, H. Q., One-Pot Multimolecular Macrocyclization for the Expedient Synthesis of Macrocyclic Aromatic Pentamers by a Chain Growth Mechanism. Chem-Asian J. 2011, 6 (12), 3298-3305.

24. Qin, B.; Ong, W. Q.; Ye, R. J.; Du, Z. Y.; Chen, X. Y.; Yan, Y.; Zhang, K.; Su, H. B.; Zeng, H. Q., Highly selective one-pot synthesis of H-bonded pentagon-shaped circular aromatic pentamers. Chem. Commun. 2011, 47 (19), 5419-5421.

23. Qin, B.; Jiang, L. Y.; Shen, S.; Sun, C.; Yuan, W. X.; Li, S. F. Y.; Zeng, H. Q., Folding-Promoted TBACI-Mediated Chemo- and Regioselective Demethylations of Methoxybenzene-Based Macrocyclic Pentamers. Org. Lett.2011, 13 (23), 6212-6215.

22. Yan, Y.; Qin, B.; Ren, C. L.; Chen, X. Y.; Yip, Y. K.; Ye, R. J.; Zhang, D. W.; Su, H. B.; Zeng, H. Q., Synthesis, Structural Investigations, Hydrogen-Deuterium Exchange Studies, and Molecular Modeling of Conformationally Stabilized Aromatic Oligoamides. J. Am. Chem. Soc. 2010, 132 (16), 5869-5879.

21. Wang, L. W.; Zhang, Q.; Zhou, X.; Liu, X. H.; Lin, L. L.; Qin, B.; Feng, X. M., Asymmetric Conjugate Addition of Nitromethane to Enones Catalyzed by Chiral N,N '-Dioxide Scandium(III) Complexes. Chem-Eur. J. 2010, 16 (26), 7696-7699.

20. Qin, B.; Ren, C. L.; Ye, R. J.; Sun, C.; Chiad, K.; Chen, X. Y.; Li, Z.; Xue, F.; Su, H. B.; Chass, G. A.; Zeng, H. Q., Persistently Folded Circular Aromatic Amide Pentamers Containing Modularly Tunable Cation-Binding Cavities with High Ion Selectivity. J. Am. Chem. Soc. 2010, 132 (28), 9564-9566.

19. Hou, Z. R.; Wang, J.; He, P.; Wang, J.; Qin, B.; Liu, X. H.; Lin, L. L.; Feng, X. M., Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper(I) Complexes of Binol Derivatives. Angew. Chem. Int. Edit.2010, 49 (28), 4763-4766.

18. Chang, L.; Kuang, Y. L.; Qin, B.; Zhou, X.; Liu, X. H.; Lin, L. L.; Feng, X. M., N,N '-Dioxide-Cu(OTf)(2) Complex Catalyzed Highly Enantioselective Amination Reaction of N-Acetyl Enamide. Org. Lett. 2010, 12 (10), 2214-2217.

17. Yan, Y.; Qin, B.; Shu, Y. L.; Chen, X. Y.; Yip, Y. K.; Zhang, D. W.; Su, H. B.; Zeng, H. Q., Helical Organization in Foldable Aromatic Oligoamides by a Continuous Hydrogen-Bonding Network. Org. Lett. 2009, 11 (6), 1201-1204.

16. Qin, B.; Chen, X. Y.; Fang, X.; Shu, Y. Y.; Yip, Y. K.; Yan, Y.; Pan, S. Y.; Ong, W. Q.; Ren, C. L.; Su, H. B.; Zeng, H. Q., Crystallographic Evidence of an Unusual, Pentagon-Shaped Folding Pattern in a Circular Aromatic Pentamer.Org. Lett. 2008, 10 (22), 5127-5130.

15. Zhou, H.; Peng, D.; Qin, B.; Hou, Z. R.; Liu, X. H.; Feng, X. M., Highly enantioselective aza-Henry reaction of N-tosyl imines catalyzed by N,N'-dioxide-Cu(I) complexes. J. Org. Chem.2007, 72 (26), 10302-10304.

14. Zheng, K.; Qin, B.; Liu, X. H.; Feng, X. M., Highly enantioselective allylation of alpha-ketoesters catalyzed by N,N'-dioxide - In(III) complexes. J. Org. Chem. 2007, 72 (22), 8478-8483.

13. Zhao, H. T.; Qin, B.; Liu, X. H.; Feng, X. M., Enantioselective trifluoromethylation of aromatic aldehydes catalyzed by combinatorial catalysts. Tetrahedron 2007, 63 (29), 6822-6826.

12. Qin, B.; Xiao, X.; Liu, X. H.; Huang, J. L.; Wen, Y. H.; Feng, X. M., Highly enantioselective henry (nitroaldol) reaction of aldehydes and alpha-ketoesters catalyzed by N,N '-Dioxide-Copper(I) complexes. J. Org. Chem. 2007, 72 (24), 9323-9328.

11. Qin, B.; Liu, X. H.; Shi, J.; Zheng, K.; Zhao, H. T.; Feng, X. M., Enantioselective cyanosilylation of alpha,alpha-dialkoxy ketones catalyzed by proline-derived in-situ-prepared N-oxide as bifunctional organocatalyst. J. Org. Chem. 2007, 72 (7), 2374-2378.

10. Huang, J. L.; Liu, X. H.; Wen, Y. H.; Qin, B.; Feng, X. M., Enantioselective strecker reaction of phosphinoyl ketoimines catalyzed by in situ prepared chiral N,N '-dioxides. J. Org. Chem. 2007, 72 (1), 204-208.

9. Lin, L. L.; Fan, Q.; Qin, B.; Feng, X. M., Highly enantio- and diastereoselective brassard type hetero-Diels-Alder approach to 5-methyl-containing alpha,beta-unsaturated delta-lactones. J. Org. Chem.2006, 71 (11), 4141-4146.

8. Wen, Y. H.; Huang, X.; Huang, J. L.; Xiong, Y.; Qin, B.; Feng, X. M., Asymmetric cyanosilylation of aldehydes catalyzed by novel organo-catalysts. Synlett 2005, (16), 2445-2448.

7. Liu, X. H.; Qin, B.; Zhou, X.; He, B.; Feng, X. M., Catalytic asymmetric cyanosilylation of ketones by a chiral amino acid salt. J. Am. Chem. Soc.2005, 127 (35), 12224-12225.

6. Li, Y.; He, B.; Qin, B.; Feng, X. M.; Zhang, G. L., Highly enantioselective cyanosilylation of aldehydes catalyzed by novel beta-amino alcohol-titanium complexes. J. Org. Chem. 2004, 69 (23), 7910-7913.

5. Chen, F. X.; Zhou, H.; Liu, X. H.; Qin, B.; Feng, X. M.; Zhang, G. L.; Jiang, Y. Z., Enantioselective cyanosilylation of ketones by a catalytic double-activation method with an aluminium complex and an N-oxide. Chem-Eur. J.2004, 10 (19), 4790-4797.

4. Chen, F. X.; Qin, B.; Feng, X. M.; Zhang, G. L.; Jiang, Y. Z., Enantioselective cyanosilylation of ketones catalyzed by double-activation catalysts with N-oxides. Tetrahedron2004, 60 (46), 10449-10460.

3. Chen, F. X.; Liu, X. H.; Qin, B.; Zhou, H.; Feng, X. M.; Zhang, G. L., Highly efficient double-activation catalysts for the synthesis of ketone cyanohydrins. Synthesis2004, (14), 2266-2272.

2. Chen, F. X.; Feng, X. M.; Qin, B.; Zhang, G. L.; Jiang, Y. Z., Highly efficient silylcyanation of ketones by a catalytic double activation method using lewis acid and N-oxide catalysts. Synlett2003, (4), 558-560.

1. Chen, F. X.; Feng, X. M.; Qin, B.; Zhang, G. L.; Jiang, Y. Z., Enantioselective cyanosilylation of ketones by a catalytic double-activation method employing chiral Lewis acid and achiral N-oxide catalysts.Org. Lett. 2003, 5 (6), 949-952.

专利

1. 一种芳香折叠体六元环的合成方法 - 201510239231.2;104876940B (授权)

2. 一种专一识别铯离子的新型有机芳香大环的制备与应用 - 201610031460.X（申请）

3. 一种温和条件下脱除酚羟基甲基保护基的方法 - 201610114850.3（申请）